Dai, X., Qiu, W., Chiu, K., Mesias, V., Liu, S., Huang, J.*, Unveiling the synergistic effect of PD-1/PD-L1 inhibitors and cisplatin in T cell-tumor cell interactions by optical tweezers coupled with Raman spectroscopy. Submitted.

Fu, W., Dai, X., Chiu, K., Mesias, V., Zhu, H., Liu, W., Huang, J.*, Real-time controlling a single molecule in hotspot for back-and-forth programmable site-specified SERS characterizations in solution. Submitted.

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Zhang, M., Li, X., Lok, C. N., Fung, Y. E., Low, K., Dai, X., Huang, J., To, W., and Che, C. M.*, Luminescent platinum(II) complexes selectively target DNA mismatches over matched DNAs with switching emission color. Submitted.

Huang, J.*, Additional label-free chemical resolution to single-molecule force spectroscopy. Biophysical Journal 2024, 123, 448a-449a.

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Li, X.-H.*, Yu, C. W. H., Gomez-Navarro, N., Stancheva, V., Zhu, H., Murthy, A., Wozny, M., Malhotra, K., Johnson, C. M., Blackledge, M., Santhanam, B., Liu, W., Huang, J., Freund, S. M.V., Miller, E. A.*, Babu, M. M.*, Dynamic conformational changes of a tardigrade group-3 late embryogenesis abundant protein modulate membrane biophysical properties, PNAS Nexus, 2024, 3, pgae006.

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Fu, W., Chi, H., Dai, X., Zhu, H., Mesias, V., Liu, W.*, Huang, J.*, Efficient optical plasmonic tweezer-controlled single-molecule SERS characterization of pH-dependent amylin species in aqueous milieus. Nature Communications, 2023, 14, 6996 (2023).

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Media coverage by EurekAlert!, Photonics, Azonano, MSN, Phys.org.https://www.eurekalert.org/news-releases/1030270

Interview and media coverage by Croucher News of Croucher Foundation.https://projects.croucher.org.hk/news/unravelling-the-foundations-of-type-2-diabetes

Zhu, H., Dai, X., Mesias, V., Chi, H., Wang, C., Chen, Q., Liu, W.*, Huang, J.*, Tunable lipid coated nanoporous silver sheet for characterization of protein-membrane interactions by surface-enhanced Raman scattering (SERS). Analytical and Bioanalytical Chemistry, 2023, 415, 3243–3253.

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Huang, J.*, Single-molecule force manipulation facilitated multiple rereads of a drug-bound DNA at specified sites by surface-enhanced Raman spectroscopy. Biophysical Journal 2023, 122, 429a.

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Xue, Y., Ruan, P., Zhu, L., Cao, Y., Fu, W., Huang, J.*, Qiu W.*, Flexible Hf6Ta2O17@ acidified carbon nanotube composite films with enhanced interfacial interaction for high-performance supercapacitors. Ceramics International, 2023, 49 (13), 22089-22099.

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Zhorabek, F., Abesekara, M., Liu, J., Dai, X., Huang, J., Chau, Y.*, Construction of multiphasic membraneless organelle towards spontaneous spatial segregation and directional flow of biochemical reactions. Chemical Science, 2023, 14, 801-811. Featured as Cover Article.

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Liu, J., Liu, X., Zhang, T., Huang, J., Tang, BZ., Chau, Y.*, Metastability of Biological Matter in Liquid Phase Separation. Applied Research. 2023, e202300071.

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Chi, H., Wang, C., Wang, Z., Zhu, H., Mesias, V., Dai, X., Chen, Q., Liu, W., Huang, J.*, Correction: Highly reusable nanoporous silver sheet for sensitive SERS detection of pesticides. Analyst, 2023, 148 (6), 1383-1383.

Citation: Analyst, 2023, 148 (6), 1383-1383. https://doi.org/10.1039/D3AN90017G.

Zhou, W., Sun, Z., Fan, J., Huang, W., Zhang, J., Song, H., Zhou, L., Huang, J., Wu, Z., Zhang, X.*, Novel solution and solid-state emissive long-wavelength carbon dots for water sensing and white LED applications. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2023, 123328.

Citation: Spectrochim. Acta A Mol. Biomol. Spectrosc. 2023, 123328. https://doi.org/10.1016/j.saa.2023.123328.

Xiao, Q., Zhou, W., Fan, J., Zhou, L., Chen, P., Mo, F., Huang, J., Liu, X., Zhang, X.*, Synthesis and luminescent properties of ZnWO4:Cr3+ nanoparticles for NIR-II fluorescence imaging. Ceramics International, 2023, 49 (15), 25682-25688.

Citation: Ceram. Int. 2023, 49 (15), 25682-25688. https://doi.org/10.1016/j.ceramint.2023.05.111.

Yi, Q., Dai, X., Park, B. M., Gu, J., Luo, J., Wang, R., Yu, C., Kou, S., Huang, J.*, Lakerveld, R.*, Sun F.*, Directed assembly of genetically engineered eukaryotic cells into living functional materials via ultrahigh-affinity protein interactions. Science Advances, 2022, 8 (44), eade0073.

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Mesias, V., Zhu, H., Tang, X., Dai, X., Fu, W., Guo, Yu., Huang, J.*, Moderate binding between two SARS-CoV-2 protein segments and α-synuclein alters its toxic oligomerization propensity differently. The Journal of Physical Chemistry Letters, 2022, 13 (45), 10642–10648. Featured as Cover Article and included in WHO global research on coronavirus disease (COVID-19).

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Li, M., Park, B. M., Dai, X., Xu, Y., Huang, J., Sun, F.*, Controlling synthetic membraneless organelles by a red-light-dependent singlet oxygen-generating protein. Nature Communications, 2022, 13, 3197 (2022).

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Dai, X., Qiu, W., Huang, J.*, Optical trapping of plasmonic nanoparticles for in situ surface-enhanced Raman spectroscopy characterizations. Journal of visualized experiments, 2022, 184, e63862. (Invited submission for the special issue of Methods Collection“Advances in Optical Trapping Biophysics”.)

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Liu, J., Zhorabek, F., Dai, X., Huang, J., Chau. Y.*, Minimalist design of intrinsically disordered protein-mimicking scaffold for artificial membraneless organelle. ACS central science 2022, 8, 493-500. Featured as Cover Article.

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Huang, J.* Combing force manipulation and Raman spectroscopy characterization to study protein structures. Biophysical Journal 2022, 121, 3a.

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Tang X., Chen R., Mesias V.S.D., Wang T., Wang Y., Poljak K., Fan X., Miao H., Hu J., Zhang L., Huang J., Yao S., Miller E.A., Guo Y*. A SURF4-to-proteoglycan relay mechanism that mediates the sorting and secretion of a tagged-variant of sonic hedgehog. Proceedings of the National Academy of Sciences 2022, 119, e2113991119.

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Zhou, W., Mo, F., Sun, Z., Luo, J., Fan, J., Zhu, H., Zhu, Z., Huang, J.*, and Zhang, X.*, Bright red-emitting P, Br co-doped carbon dots as “OFF-ON” fluorescent probe for Cu2+ and L-cysteine detection. Journal of Alloys and Compounds, 2022, 897, 162731.

Citation: J. Alloys Compd. 2022, 897, 162731. https://doi.org/10.1016/j.jallcom.2021.162731.

Chen, Z., Huang, J., Li, J.*, Protein purification, crystallization, and structure determination of human DEAD-box RNA helicase DDX21 in different unwinding states. STAR Protocols, 2022, 3, 101642.

Citation: STAR Protocols, 2022, 3, 101642.https://doi.org/10.1016/j.xpro.2022.101642 .

Sun, Z., Zhou, W., Luo, J., Fan, J., Wu, Z.-c., Zhu, H., Huang, J., Zhang, X.*, High-efficient and pH-sensitive orange luminescence from silicon-doped carbon dots for information encryption and bio-imaging. Journal of Colloid and Interface Science, 2022, 607, 16-23.

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Zhou, W., Liu, C., Fan, J., Luo, J., Liu, L., Huang, J., Liu, R.*, Zhang, X.*, Red-emitting carbon dots as luminescent agent in wide-range water detection in organic solvents and polarity-selective zebrafish imaging. Journal of Alloys and Compounds, 2022, 920, 165963.

Citation: J. Alloys Compd. 2022, 920, 165963. https://doi.org/10.1016/j.jallcom.2022.165963 .

Dai, X., Fu, W., Chi, H., Mesias, V., Zhu, H., Leung, C. W., Liu, W.*, and Huang, J.*, Optical tweezers-controlled hotspot for sensitive and reproducible surface-enhanced Raman spectroscopy characterization of native protein structures. Nature Communications, 2021, 12, 1292 (2021).

Citation: Nat. Commun. 2021, 12, 1292. https://doi.org/10.1038/s41467-021-21543-3.

Media coverage by EurekAlert!, ScienMag, Photonics, Azooptics, Phys.org, Alzform, Drug Target Review, Bioengineer.org.https://www.eurekalert.org/news-releases/779412

Chinese media 中文媒體報導: https://mp.weixin.qq.com/s/J6qf3GfLZZFwdqQFtDCmNQ

Dai, X., Fu, W., Chi, H., Mesias, V., Zhu, H., Leung, C. W., Liu, W.*, Huang, J.*, Fabrication of Silver Nanoparticle coated Silica Beads. Protocol Exchange on Research Square 2021, PPR291931.

Citation: Dai, Xin, et al. "Fabrication of silver nanoparticle coated silica beads." Protoc. Exch (2021).https://doi.org/10.21203/rs.3.pex-1345/v1 .

Mesias, V. S. D., Zhu, H., Tang, X., Dai, X., Guo, Y., Liu, W., and Huang, J.*, Effective ACE2 peptide–nanoparticle conjugation and its binding with the SARS-Cov-2 RBD quantified by dynamic light scattering. Chemical Communications, 2021, 57, 6979-6982.

Citation: Chem. Commun. 2021, 57, 6979-6982 https://doi.org/10.1039/D1CC02267A.

Yeung, C. S., Tse, H.-Y., Lau, C. Y., Guan, J., Huang, J., Phillips, D. L.*, and Leu, S.-Y.*, Insights into unexpected photoisomerization from photooxidation of tribromoacetic acid in aqueous environment using ultrafast spectroscopy. Journal of Hazardous Materials, 2021, 418, 126214.

Citation: J. Hazard. Mater. 2021, 418, 126214 https://doi.org/10.1016/j.jhazmat.2021.126214.

Li, X.; Pei, Y.; Zhang, Y.; Liu, Y.; Fu, W.; Li, J.; You, H.*; Huang, J.*, Single-molecule mechanical unfolding of AT-rich chromosomal fragile sites DNA hairpins: Resolving the thermodynamic and kinetic effects of single G-T mismatch. The Journal of Physical Chemistry B, 2020, 124, 42, 9365–9370. Featured as Cover Article.

Citation: J. Phys. Chem. B 2020, 124, 42, 9365–9370. https://doi.org/10.1021/acs.jpcb.0c06954.

Chi, H., Wang, C., Wang, Z., Zhu, H., Mesias, V., Dai, X., Chen, Q., Liu, W., Huang, J.*, Highly reusable nanoporous silver sheet for sensitive SERS detection of pesticides. Analyst, 2020, 145, 5158-5165. Featured as Cover Article.

Citation: Analyst 2020, 145, 5158-5165. https://doi.org/10.1039/D0AN00999G.

Chen, Z., Hu, X., Xie, F., Li, Z., Kuang, S., Zhan, B., Gao, W., Chen, X., Gao, S., Li, Y., Wang, Y., Qian, F., Ding, C., Gan, J., Ji, C., Zhou, Z., Huang, J., He, H. H., Li. J.*, Structural basis of human helicase DDX21 in RNA binding, unwinding, and antiviral signal activation. Advanced Science, 2020, 7, 2000532.Featured as Cover Article.

Citation: Adv. Sci. 2020, 7, 2000532. https://doi.org/10.1002/advs.202000532.

Huang, J., Muliawan, A., Ma, J., Li, M. D., Chiu, H. K., Lan, X., and Phillips, D. L.*, “A Spectroscopic Study on the Excited State Proton Transfer Process of 8-Bromo-7-Hydroxyquinoline-Phenol in Aqueous Conditions”, Photochemical & Photobiological Sciences, 2017, 16, 575-584.

Huang, J., Parobek, A., Ganim, Z.*, “Octave-spanning mid-infrared pulses by plasma generation in air pumped with an Yb:KGW source”, Optics letters, 2016, 41, 4855-4858

Liu, M., Li, M. D., Huang, J., Li, T., Liu, H., Li, X., and Phillips, D. L.*, “Substituent Effects on the Photodeprotection Reactions of Selected Ketoprofen Derivatives in Phosphate Buffered Aqueous Solutions”, Scientific Report, 2016, 6, 21606.

Huang, J., Ma, J., Li, M. D., Liu, M., Zhang, X., and Phillips, D. L.*, “How does the C-Halogen Bond Break in the Efficient Photosubstitution Reaction of 3-Fluorobenzophenone but not for 3-Chlorobenzophenone and 3-Bromobenzophenone in Acidic Aqueous Solutions?”, Journal of Organic Chemistry, 2015, 80, 9425-9436.

Li, M. D., Huang, J., Liu, M., Li, S., Ma, J., and Phillips, D. L.*, “Investigation of the Role of Protonation of Benzophenone and Its Derivatives in Acidic Aqueous Solutions Using Time Resolved Resonance Raman Spectroscopy: How Are Ketyl Radicals Formed in Aqueous Solutions?”, Journal of Physical Chemistry B. 2015, 119, 2241-2252.

Huang, J., Yeung, C. S., Ma, J., Gayner, E. R., and Phillips, D. L.*, “A Computational Chemistry Investigation of the Mechanism of the Water-Assisted Decomposition of Trichloroethylene Oxide”, Journal of Physical Chemistry A, 2014, 118, 1557-1567.

Xue, J., Du, L., Zhu, R., Huang, J., and Phillips, D. L.*, “Direct Time-Resolved Spectroscopic Observation of Arylnitrenium Ion Reactions with Guanine-Containing DNA Oligomers”, Journal of Organic Chemistry, 2014, 79, 3610-3614.

Ma, J., Su, T., Li, M. D., Zhang, X., Huang, J., and Phillips, D. L.*, “meta versus para Substitution: How Does C–H Activation in a Methyl Group Occur in 3-Methylbenzophenone but Does Not Take Place in 4-Methylbenzophenone?”, Journal of Organic Chemistry, 2013, 78, 4867-4878.

Ma, J., Su, T., Li, M. D., Du, W., Huang, J., Guan, X., and Phillips, D. L.*, “How and When Does an Unusual and Efficient Photoredox Reaction of 2-(1-Hydroxyethyl) 9,10-Anthraquinone Occur? A Combined Time-Resolved Spectroscopic and DFT Study”, Journal of American Chemical Society, 2012, 134, 14858-14868.

Zhang, X., Zhang, J., Huang, J., Tang, X., and Gong, M.*, “Synthesis and Luminescence of Eu2+-doped Alkaline-Earth Apatites for Application in White LED”, Journal of Luminescence, 2010, 130, 554-559.

Zhang, X., Wang, X., Huang, J., Shi, J., and Gong; M.*, “Near UV-based LED Fabricated with Ba5SiO4(F,Cl)6:Eu2+ as Blue- and Green-Emitting Phosphor”, Optical Materials, 2009, 32, 75-78.